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The crystal structures of your MIF-inhibitor complexes had been utilised given that the Original templates check here for virtual screening. The Protein Preparation Wizard module in Schrödinger was made use of to arrange Each individual MIF elaborate. The ligand situated during the Lively web page amongst chains A and B was managed. The sophisticated was then refined With all the OPLS drive area [26]. Pro1, a very important nucleophilic residue, was protonated In line with experimental and theoretical benefits [27].
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